Important Safety Information

This page summarizes important safety information for prescription pathways that may be offered through Eterna IQ membership. It does not replace conversations with your clinician or the full prescribing information for your specific medication.

Eterna IQ is a health technology company, not a prescriber. Prescribing decisions are made by independent licensed clinicians.

**DRAFT:** Clinical text below requires medical director and pharmacy sign-off before publish. Do not treat this page as final labeling.

Prescription therapies offered through Eterna membership may include compounded preparations from licensed partner pharmacies.

Compounded drugs are not FDA-approved drug products. The FDA does not review compounded drugs for safety, effectiveness, or quality before they are marketed.

[Counsel and pharmacy: state the legal basis for compounding (503A patient-specific / 503B outsourcing facility) and maintain as FDA shortage listings change.]

When prescribed for chronic weight management in appropriate patients, GLP-1 class therapies have important risks.

**Thyroid C-cell tumors:** In rodents, semaglutide caused thyroid C-cell tumors. It is unknown whether this occurs in humans. Do not use if you or a family member have had medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Tell your clinician about a neck lump, trouble swallowing, or hoarseness.

Other serious risks may include pancreatitis, gallbladder disease, kidney problems from dehydration, hypoglycemia (especially with insulin or sulfonylureas), allergic reactions, and vision changes in patients with diabetic eye disease.

Do not use if pregnant or planning pregnancy without clinician guidance. Common side effects include nausea, vomiting, diarrhea, constipation, abdominal pain, headache, and fatigue.

When prescribed for chronic weight management in appropriate patients, tirzepatide has a similar risk profile to other GLP-1 class therapies.

**Thyroid C-cell tumors:** Do not use if you or a family member have had MTC or MEN 2. Seek care for neck mass, trouble swallowing, or persistent hoarseness.

Other serious risks may include pancreatitis, gallbladder disease, kidney problems, hypoglycemia, and allergic reactions.

Do not use if pregnant or planning pregnancy without clinician guidance. Common side effects include nausea, diarrhea, vomiting, constipation, abdominal pain, and decreased appetite.

Testosterone therapy requires baseline and ongoing laboratory monitoring. Risks may include polycythemia (elevated red blood cell count), fertility effects, acne, fluid retention, sleep apnea worsening, and cardiovascular effects in some patients.

Testosterone can transfer to partners or children through skin contact. Follow clinician instructions for application site hygiene and covering treated skin.

TRT is not appropriate for everyone. Your clinician will review contraindications, including certain cancers, untreated severe sleep apnea, and uncontrolled heart failure.

NAD+ therapies offered through membership are commonly compounded and used off-label for wellness and energy support when a clinician determines they are appropriate.

Compounded NAD+ is not an FDA-approved drug product. Risks may include injection site reactions, flushing, nausea, and interactions with other treatments.

Do not use NAD+ therapies without clinician review of your medications, pregnancy status, and relevant medical history.

Hormone-related therapies (including clomiphene, enclomiphene, or DHEA when prescribed) require individualized evaluation and monitoring.

Risks vary by agent and may include mood changes, fertility effects, liver enzyme changes, and cardiovascular or metabolic effects. Follow all laboratory monitoring recommended by your clinician.

Contact your treating clinician promptly for concerning symptoms. For emergencies, call 911.

You may report side effects to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch.

Not all risks are listed here. Read all information provided with your medication and ask your clinician questions.

Clinical questions should be directed to your treating clinician. Platform questions: support@eternaiq.com.

Eterna IQ, Inc.